Sunday, April 7, 2013

EU: No deal reached at nuclear talks with Iran

Secretary of Iran?s Supreme National Security Council, Saeed Jalili grimaces while listening to a question during his news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

Secretary of Iran?s Supreme National Security Council, Saeed Jalili grimaces while listening to a question during his news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

EU foreign policy chief Catherine Ashton leaves her news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

Secretary of Iran?s Supreme National Security Council, Saeed Jalili listens to a question during his news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

Secretary of Iran?s Supreme National Security Council, Saeed Jalili prepars to listen to a question during his news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

EU foreign policy chief Catherine Ashton answers a question during her news conference after the high-level talks between world powers and Iranian officials in Almaty, Kazakhstan, Saturday, April 6, 2013. Iran and six world powers failed to reach agreement Saturday on a common approach to reducing fears that Tehran might misuse its nuclear technology to make weapons, with the EU?s foreign policy chief declaring that the to sides ??remain far apart on substance.?? (AP Photo/Pavel Mikheyev)

(AP) ? Iran and six world powers failed to reach agreement Saturday on how to reduce fears that Tehran might use its nuclear technology to make weapons, extending years of inconclusive talks and adding to concerns the diplomatic window on reaching a deal with Tehran may soon close.

Expectations the negotiations were making progress rose as an afternoon session continued into the evening. But comments by the two sides after they ended made clear that they fell far short of making enough headway to qualify the meeting as a success.

"What matters in the end is substance, and ... we are still a considerable distance apart," Catherine Ashton, the European Union's head of foreign policy, told reporters at the end of the two-day talks.

Ashton, the convener of the meeting, said negotiators would now consult with their capitals. She made no mention of plans for new talks ? another sign that the gap dividing the two sides remains substantial. She said she would talk with chief Iranian negotiator Saeed Jalili by telephone over further steps.

Jalili spoke of "some distance between the positions of the two sides." He suggested Iran was ready to discuss meeting a key demand of the other side ? cutting back its highest-grade uranium enrichment production and stockpile ? but only if the six reciprocated with rewards far greater than they are now willing to give.

While no breakthrough had been expected, the lack of forward movement in international negotiations that started a decade ago was certain to increase concerns that diplomacy was ineffective as a tool to stop Iran from moving toward nuclear-weapon making capacity.

Israel is most worried. The Jewish state says Iran is only a few months away from the threshold of having material to turn into a bomb and has vowed to use all means to prevent it from reaching that point. The U.S. has not said what its "red line" is, but has said it will not tolerate an Iran armed with nuclear weapons.

"The Iranians are using the round of talks to pave the way toward a nuclear bomb," said Yuval Steinitz, the Israeli minister for intelligence and strategic affairs, in a text message to reporters. "Israel has already warned that the Iranians are taking advantage of the rounds of talks in order to buy time to advance in uranium enrichment, step by step, toward a nuclear weapon."

Urging the international community to set a "short, clear and final timetable" for further talks, he said "the time has come for the world to show a more aggressive position and make it abundantly clear to the Iranians that their game of negotiations is coming to an end."

Any strike on Iran could provoke fierce retaliation directly from Iran and through its Middle East proxies in Syria, Lebanon and Palestine, raising the specter of a larger Middle East conflict and adding to the urgency of keeping both sides at the negotiating table.

At the talks in the Kazakh city of Almaty, the U.S., Russia, China, Britain, France and Germany were asking Tehran to greatly limit its production and stockpiling of uranium enriched to 20 percent, which is just a technical step away from weapons-grade uranium. That would keep Iran's supply below the amount needed for further processing into a weapon.

But the group views that only as a first step in a process. Iran is operating more than 10,000 centrifuges. While most are enriching below 20 percent, this material, too could be turned into weapons-grade uranium, although with greater effort than is the case for the 20-percent stockpile.

Tehran also is only a few years away from completing a reactor that will produce plutonium, another pathway to nuclear arms.

The U.N. Security Council has demanded a stop to both that effort and all enrichment in a series of resolutions since 2006. Iran denies any interest in atomic arms, insists its enrichment program serves only peaceful needs, says it has a right to enrich under the Nuclear Nonproliferation Treaty and describes U.N. Security Council demands as illegal.

The lack of progress at Almaty was a clear indication that Tehran wants greater rewards for any concessions that the six are ready to give. Among other incentives, they have offered to lift sanctions on Iran's gold transactions and petrochemical trade. But Iran demands much more substantial sanctions relief, including an end to international penalties crippling its oil trade and financial transactions

A senior U.S. official cited Iranian officials who described the six-power offer of limited sanctions relief in exchange for meeting their demands on 20-percent uranium as a "turning point" when the two sides met last month. The official said the U.S. administration was "disappointed that this rhetoric did not carry over into our negotiations."

The official demanded anonymity as a condition for participation in a post-meeting briefing for reporters.

Jalili in turn urged the six powers to demonstrate their "willingness and sincerity" by taking appropriate confidence-building steps in the future" ? shorthand for Iran's demand to lift major sanctions and offer other concessions.

At the same time, he suggested some potential give on the Iranian side, suggesting discussion on some curbs of 20-percent enrichment "can be continued in the talks" if the six "move away from hostile treatment ... of the Iranian people."

With Iran previously describing the crushing sanctions on its oil exports and financial transactions as hostile acts, his comments suggested that Iran would consider compromise only if those penalties were lifted. That is far more than the relief being offered, with the six prepared to remove sanctions only on Tehran's gold transactions and petrochemical exports.

In demanding recognition of its right to enrich, Iran may hope to exploit some differences among the six, with Russia in recent months pushing for concessions on that point as a way to break negotiating deadlock.

Russian Deputy Foreign Minister Sergei Ryabkov, who led his country's delegation at Almaty, said after the talks that Moscow "considers that it's necessary to recognize all rights of Iran, including enrichment." In exchange, he said Iran must accept more international monitoring of its nuclear program.

A British Foreign Office statement said "a wide gap remains between the parties. Iran's current position falls far short of what is needed to achieve a diplomatic breakthrough."

Indirectly warning of further sanctions, the statement urged Tehran to "consider carefully whether it wants to continue on its current course, and face increasing pressure and isolation from the international community, or to enter into meaningful negotiations."

But Ryabkov described the meeting as "undoubtedly a step forward." Those remarks, and his comments on enrichment, both to Russian news agencies, suggested differences exist among the six, despite assertions by negotiators from Western nations of total unity at the negotiations.

___

Associated Press writers Mansur Mirovalev in Almaty, Daniel Estrin in Jerusalem, James Heinz in Moscow and Cassandra Vinograd in London contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-06-Iran-Nuclear/id-eca2d81ea7ea465587551db750fefc02

Big Bird Adam Greenberg Fall Leaves Jim Lehrer 666 Park Avenue Kara Alongi Sahara Davenport

Friday, April 5, 2013

Penn Medicine's new center for personalized diagnostics unlocks cancer's secrets

Apr. 5, 2013 ? Just like a massive iceberg jutting out of the ocean, many of cancer's genetic underpinnings remain hidden under the surface, impossible to predict or map from above. The foreboding shadows and shapes that appear on CT scans and MRIs -- and even in the field that doctors see when they zoom in to look at cancer cells under a high-powered microscope -- are just the tip of the iceberg.

Penn Medicine's new Center for Personalized Diagnostics, a joint initiative of the department of Pathology and Laboratory Medicine in the Perelman School of Medicine and the Abramson Cancer Center, is diving deeper into each patient's tumor with next generation DNA sequencing. These specialized tests can refine patient diagnoses with greater precision than standard imaging tests and blood work, all with an aim to broaden treatment options and improve their efficacy.

"We're using the most advanced diagnostic methods to unlock cancer's secrets," says David B. Roth, MD, PhD, chairman of the department of Pathology and Laboratory Medicine. "A tumor's genomic profile is the most critical piece of information for an oncologist to have when they're deciding what therapy to recommend. The results of tests in the Center for Personalized Diagnostics reveal a genetic blueprint of each patient's tumor that is as discrete and singular as a fingerprint."

The Center for Personalized Diagnostics unites top experts in genomic analysis, bioinformatics, and cancer genetics -- who use the most sensitive data analysis tools available to identify the rarest of mutations -- with oncologists who treat patients and design clinical trials to test new therapies. Together, their efforts will provide cancer patients with cutting-edge diagnostic and therapeutic options.

The first group of patients who are undergoing testing through the CPD includes those with blood cancers and solid tumors of the brain, melanoma, and lung. Throughout 2013, the tests will be expanded for a wider range of cancer patients. Results are available within two weeks -- twice as fast as most commercially available testing panels. All new and relapsed Abramson Cancer Center patients will receive this testing -- conducted via simple blood tests and/or biopsy of tumor tissue or bone marrow -- as part of their evaluation and diagnostic process. Interpretation of results is communicated one-on-one to patients and their caregivers by physicians and genetic counselors.

In contrast to the CPD's offerings, individual genetic tests -- which now proliferate in the marketplace, even for healthy people who may be interested in going on a spelunking expedition through their DNA -- are time consuming and expensive to conduct, and they often yield information which is not clinically actionable. When these tests are offered for cancer patients, patients are often left with only a veritable alphabet soup detailing genetic information, with few plans for how to use those findings to conquer their cancer.

Since the CPD began operating in early 2013, however, tests in 80 percent of patients revealed genetic mutations that may be used to alter their treatment course or clarify their prognosis. The results are playing a role in:

  • Matching patients with existing therapies designed to target mutations previously associated only with different cancers. For instance, some lung cancer patients exhibit mutations of the BRAF gene, which is targeted by drug Vemurafenib, initially developed and approved for melanoma. Testing in the Center for Personalized Diagnostics is helping clinicians make new connections that will expand the indications for existing drugs.
  • Helping physicians determine which treatments a patient will respond to, or how well they will tolerate a particular treatment. Patients with the blood cancer acute myelogenous leukemia who express a mutation known as DNMT3A, for instance, are known to respond to higher doses of the drug daunorubicin. Learning this type of information prior to beginning treatment can help oncologists select and dose drugs in a way that will reduce side effects and boost patients' quality of life during treatment -- and increase their chance of completing their prescribed regimen.
  • Identifying patients who are likely to have a poor prognosis if treated with first-line therapies, which allows clinicians to set up a cascade of alternative therapies or, in the case of some blood cancer patients, expedite the search for a matching bone marrow donor.
  • Detecting resistance mutations that could slow or halt patients' response to targeted drugs, which allows for custom-designed combination therapies to attack tumors through multiple pathways.

The Center's research agenda operates in parallel with its clinical care mission. Each patient's test results will add to an enormous repository of genomic mutation profiles that, combined with the ability to follow patients over time, will help clinical researchers identify new markers and mutation profiles to better predict the course of an individual patient's treatment response and suggest new targets for therapy. As new mutations are detected and novel treatment options are identified, the gene testing panels will be modified and expanded, creating an evolving, real-time mutation profiling option.

"We see 11,500 newly diagnosed patients each year in the Abramson Cancer, and hundreds of others who seek our help when their cancers have not responded, or have returned, after receiving standard therapies elsewhere," said Chi Van Dang, MD, PhD, director of the Abramson Cancer Center. "A key part of our mission is to provide each of these patients these tests as soon as possible, so that we can quickly tailor a treatment regimen that provides them the greatest chance of a cure."

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Perelman School of Medicine at the University of Pennsylvania.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/m4ztSlvAFzs/130405104723.htm

agoraphobia andrew lloyd webber obscura grok cirque du freak paul pierce pope joan

He was a splendid military gambler, dominating the problems of...

He was a splendid military gambler, dominating the problems of supply and scornful of opposition?? His ardor and daring inflicted grievous disasters upon us, but he deserves the salute which I made him ? and not without some reproaches from the public ? in the House of Commons in January 1942, when I said of him, ?We have a very daring and skillful opponent against us, and, may I say across the havoc of war, a great general.?

He also deserves our respect because, although a loyal German soldier, he came to hate Hitler and all his works, and took part in the conspiracy to rescue Germany by displacing the maniac and tyrant.?For this, he paid the forfeit of his life. In the sombre wars of modern democracy, chivalry finds no place ? Still, I do not regret or retract the tribute I paid to Rommel, unfashionable though it was judged.

Source: http://scuttlebuttstuch.tumblr.com/post/47214608140

anna paquin warren buffett 2012 nfl schedule dishonored april 18 delonte west vanessa williams

Friday, March 29, 2013

Brew Edition: 5 Manual Coffee-Making Gadgets Tested

Brew Edition: 5 Manual Coffee-Making Gadgets Tested
If you're still using an automatic coffee-maker, you're doing it wrong. We test five different manual coffee-brewing systems.

Source: http://www.wired.com/gadgetlab/2013/03/brew-edition-5-manual-coffee-making-gadgets-tested/

CES 2013 joe budden notre dame notre dame football Bcs Bowl Chuck Hagel ncaa football

Pro-ject's Colorful Turntables Please Your Eyes and Your Ears

So you've decided to hop on the vinyl trend. You need a turntable. Pro-ject's candy hued Debut Carbon tables will appeal to both your eyes and your ears. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/QBVCEEz5Dys/pro+jects-colorful-turntables-please-your-eyes-and-your-ears

april 4 santa monica college wisconsin primary dallas fort worth airport texas tornados seattle seahawks new uniforms wisconsin recall

Creative SEO Tip: Newsjacking - Search Engine Watch (#SEW)

newsjacking

Google is growing market share and vowing to implement more changes aimed at reducing web spam and manipulative linking. But to the average small business owner these constant changes are mystifying or even maddening. To small businesses, Google seems to be sending a consistent message: Link building, in all forms, is manipulative and bad.

But this can?t be true. We know that Google?s algorithm runs on links at the core. How can there be such a disparity between what everyone knows to be true and the message Google sends to marketers?

First Reaction: Give Up on SEO

In the face of continuing Google updates and a desire to stay ?clean,? most marketers flirt with the idea of giving up on SEO entirely and turn to PPC. PPC should be in the marketing portfolio already, as it is an excellent complement to search engine optimization.

PPC should be used for testing new keyword spaces, end-user reactions to copy, time-on-site and conversion behaviors. It is the right tool because it brings traffic quickly. But long term, PPC is expensive and estimating PPC ROI is difficult.

The next target is social media. Social media has serious media hype behind it, leading many to believe it is a viable alternative to SEO.

While social media is critical for public relations, customer service and reputation management, data strongly suggests that social media is not a great source of first-time visitors?(i.e., leads) for small businesses. Like PPC, social media is an important part of a diversified marketing strategy. And it is vital for content marketing. But it is not a silver bullet.

Second Reaction: Do SEO Faster (and More Poorly)

Faced with the realization that SEO has the strongest ROI, small business marketers often come to the conclusion that they just need to do SEO faster. Sadly, this usually means cutting corners and doing SEO more poorly.

Thin content is not a viable onsite SEO strategy. Furthermore, thin content placed in low-authority article directories does not bring strong results. Guest blog posts can be very beneficial, but not on unrelated websites. In short, link manipulation techniques that may have worked 4 years ago are now detrimental.

Avoid bad link building techniques, as Google has gotten much stronger as spotting link manipulation attempts and schemes. Don?t use spammy blog networks or buy links from shady websites. Don?t make articles without co-citation and then spin them. This is not helpful to the end-user and leaves a bad footprint in the link graph.

Final Reaction: SEO Requires Effort, Purpose and Creativity

After the dust settles (or a webmaster receives a penalty), the smart marketer starts viewing the costs associated with good SEO as a wise investment. At this point, they start to think creatively about SEO and explore the full potential of inbound marketing. They invest in building relationships while they are building links, which to the uninitiated may not even make sense. Relationships breed accountability whereas anonymity does not.

After drinking the SEO Kool-Aid, marketers recognize that their link building should be in the form of content that has real purpose and value?to the end-reader.

In short, they transform from link building SEO professionals to content marketers. They start writing for a real audience, caring about facts and statistics. The presentation of content is upgraded with relevant images and is never reused. Content is syndicated to higher-value websites now that it takes longer to procure. The end-result is stronger for end-users, and marketers invariably start to look for more creative ways to syndicate content with the hopes of something going viral.

Creative SEO Tip: Newsjacking

Newsjacking is a newer idea in SEO, but a natural extension of content marketing. While it sounds like a negative term, it is not. Newsjacking is a technique in which marketers ride existing demand associated with breaking news for exposure. In other words, smart marketers know there is extremely high demand for breaking news stories and use this to their advantage by contributing to the overall discussion.

What is newsjacking?

  • Paying attention to breaking news
  • Understanding the keywords being searched for in a particular news cycle
  • Producing high-quality, well-researched content that serves a specific demand for information
  • Syndicating content very quickly to be found when other news organizations search for sources.

Small businesses can?t newsjack any story, it has to be related to their space. But most businesses won?t have difficulty finding breaking news that somehow relates to their business.

For example, a high profile fire in a historic building could be used by a construction company to highlight the importance of local code and inspections. A bank robbery could be used by a home security company to discuss the merits of a reliable security system. In both cases, working in a natural sentence that highlights the company?s position will not be difficult.

Newsjacking is similar to content marketing in that the content comes first and the marketing second. Serve the reader?s desire for news, facts and opinion ? but use that opportunity for a branded mention and a link (yes, it is still OK to get a link when you work for it). Finally, use social media for quick dissemination and viral spread. Recognize that unlike content marketing, newsjacking is fleeting and timing is critical.

Conclusions

Regardless of the debate on Google?s effectiveness today, all agree that Google will continue to make updates to its algorithm to spot unnatural link manipulation. Smart marketers understand this trend, but don?t want to give up on SEO due to the ROI.

After exhausting PPC and social media, SEO professionals turn to high-quality, creative techniques to contribute valuable content while gaining exposure and links. Content Marketing is a well-established technique.

Newsjacking, a type of content marketing, places the emphasis on breaking news events rather than how-tos or technical Information and rides the wave of existing demand for news information to get well-earned backlinks and branded mentions.


ClickZ & Efectyv Marketing

Convergence Analytics: Digital Measurement in Transition
This joint report by ClickZ and Efectyv Marketing seeks to identify how the evolution of digital analytics affects and challenges practitioners, vendors, and investors. Download it today!

Source: http://searchenginewatch.com/article/2258014/Creative-SEO-Tip-Newsjacking

sarah burke death etta james funeral erin brockovich dodgeball 2012 pro bowl postsecret ufc on fox 2

Fisker puts US workers on furlough to conserve cash

Fisker puts US workers on furlough to conserve cash

Fisker's cash reserves have been in trouble ever since its Department of Energy loans were frozen, and now its putting its US workforce on furlough to keep money in the bank while it searches for a partner with deep pockets. "This is a common practice, particularly in the automotive industry, to manage costs and operations based on current activity levels and commercial requirements," said Fisker, which has over 200 employees in America, in a statement concerning the unpaid leave. Considering that battery woes and other mishaps have contributed to keeping assembly lines quiet, current activity levels are indeed low. Reuters says the automaker hasn't built a car since July, and it's coming up against a federal loan payment in late April. According to the outlet, Fisker was aiming to partner with Chinese auto companies that could bolster its finances, but talks are said to have crawled to a stop. Regardless, the firm is still on the lookout for an investor to fuel the production of its Atlantic hybrid.

Filed under:

Comments

Source: Reuters

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ESgcYwSHI88/

anencephaly tesla model x lou gehrig toby mac blue ivy carter photos purple squirrel blade runner